Thursday, October 20

Women with unexplained infertility are at heightened risk for having undiagnosed celiac disease

Women with unexplained infertility are at heightened risk for having undiagnosed celiac disease (CD), which may be a modifiable and treatable risk factor, research suggests.

To determine whether an increased prevalence of undiagnosed CD might exist among a population of infertile women, investigators conducted a prospective cohort study at a U.S. infertility clinic. Serologic screening uncovered CD in four of 188 subjects, translating to an overall prevalence in this population of 2.1%.

Although this rate was not significantly higher than the expected 1.3%, undiagnosed CD was significantly more prevalent in the subset of 51 women presenting with unexplained infertility: Three (5.9%) of these women had previously undiagnosed CD (J Reprod Med. 2011;56:199-203).

All four women found to have CD underwent nutrition counseling to help them change over to a gluten-free diet. All four became pregnant within a year of diagnosis.

"Diagnosing CD in an infertile woman would be particularly beneficial if the low-cost (and low-risk) therapy of pursuing a gluten-free diet could improve chances for conception," study researcher, Janet Choi, MD, said in a statement.
From the October 2011 Issue of Clinical Advisor

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