With no scientific evidence to back up their suspicions, they are willing - but extremely cautious - to treat women like a 31-year-old Johannesburg businesswoman who has been trying to have a baby for four and a half years, but has too many NK cells.
The woman, who wants to be known only as Chantal, said: "I've done pregnancy tests each month, but to see the stick with the one line on it, instead of two, can crush you," she said.
Dr Merwyn Jacobson, medical director of Vitalab centre for assisted conception in Johannesburg, said: "We're trying to find explanations for things we don't understand. We may be way out and have to eat humble pie, but that's our thinking as of now."
During early pregnancy there is a dramatic increase in the number of NK cells, which search for and destroy harmful cells in the body.
Based on research by controversial British infertility specialist Dr George Ndukwe, Jacobson and his colleagues Dr Lawrence Gobetz and Dr Stephen Volschenk think over-reactive NK cells in the uterus attach to the growing embryo and destroy it because the killer cells view it as an "invader".
My notes: I have been espousing this pathomechanism for years. Herbs help to mitigate activate natural killer cells in addition to IVIG or intralipid therapy. mike berkley, L.AC., FABORM
Monday, October 31
Thursday, October 27
Preserving Your Fertility - You're Invited
START SPREADING THE NEWS!
New York Fertility Services
Presents a free event
Stop The Clock
Preserving Your Fertility
Tuesday, November 15th, 2011
6:30pm – 8:00pm
16 E. 40th Street, 2nd Floor
New York, NY 10016
If you are single, in a relationship, or newly married and are wondering how long you can wait to start your family, this event is for you! Please join us for an evening of information about Age and Fertility. Dr. Joel Batzofin will address these topics:
Infertility and Age – Where are you? How does one affect the other?
Egg Freezing and Fertility Preservation – Can we “stop the clock”?
Success Rates – What exactly do they mean?
Egg Freezing Cycle Costs – Can I afford to do this? Can I afford NOT to?
Hors d’oeuvres will be served so bring your friends along to this informative event. We will have a drawing for a free Egg Freezing Cycle* to one lucky person who attends this event – you must be present to win. We will also offer a special “End of the Year” Egg Freezing Cycle Incentive for all who attend to help you preserve your fertility now so you can concentrate on living your life!
Reservations are a must.
RSVP to Teresa attrandolph@nyfsb.com or call 212-679-2289.
New York Fertility Services
Presents a free event
Stop The Clock
Preserving Your Fertility
Tuesday, November 15th, 2011
6:30pm – 8:00pm
16 E. 40th Street, 2nd Floor
New York, NY 10016
If you are single, in a relationship, or newly married and are wondering how long you can wait to start your family, this event is for you! Please join us for an evening of information about Age and Fertility. Dr. Joel Batzofin will address these topics:
Infertility and Age – Where are you? How does one affect the other?
Egg Freezing and Fertility Preservation – Can we “stop the clock”?
Success Rates – What exactly do they mean?
Egg Freezing Cycle Costs – Can I afford to do this? Can I afford NOT to?
Hors d’oeuvres will be served so bring your friends along to this informative event. We will have a drawing for a free Egg Freezing Cycle* to one lucky person who attends this event – you must be present to win. We will also offer a special “End of the Year” Egg Freezing Cycle Incentive for all who attend to help you preserve your fertility now so you can concentrate on living your life!
Reservations are a must.
RSVP to Teresa attrandolph@nyfsb.com or call 212-679-2289.
ivf and cancer
Ovarian Malignancy Risk Seen Doubled 15 Years After IVF By: JENNIE SMITH, Family Practice News Digital Network.
Women who have undergone in vitro fertilization appear to have a twofold risk of ovarian malignancies later in life, compared with women with fertility problems who never used IVF.
However, the risk of invasive ovarian cancer was not significantly increased in IVF-treated women until 15 years after IVF treatment, the results of the study found.
Results from a large Dutch cohort study of 25,152 women using linked medical records to identify women who had been seen for infertility and/or treated with IVF from 1983 to 1995 showed that borderline ovarian tumors accounted for most of the increase in risk after a median 15 years of follow-up. Most of the women were in their late 40s at the study end point.
The investigators of the study, which was published Oct. 26 in Human Reproduction, compared the 19,146 IVF-treated women in the cohort with a control group of 6,006 women who had been seen for fertility problems but had not undergone IVF (although they may have received other forms of treatment, including drugs). The investigators also looked at rates of ovarian malignancies in the general population (Hum. Reprod. 2011 [doi:10.1093/humrep/der322]).
Having subfertile controls was important, the investigators said, because women with infertility have a different risk profile for ovarian malignancies than do women in the population at large. Causes of infertility in the study included fallopian tube disorders, subfertility of a male partner, cervical factor, and endometriosis.
The investigators, led by Flora E. van Leeuwen, Ph.D., of the Netherlands Cancer Institute in Amsterdam, noted that the findings of a risk increase for ovarian malignancies confirmed older findings from smaller cohort studies. Borderline tumors are considered to have a low malignancy potential, and not much is known about which will become invasive, but these tumors do require treatment.
Nearly half of the 61 malignancies detected in the IVF-treated women were borderline tumors, while in the general population of women under age 50 years, these normally account for 15%-30% of malignancies, Dr. van Leeuwen and her colleagues found. A high proportion – 63% – of the borderline tumors seen in the IVF-treated group were serous, while mucinous tumors are more frequent in the general population.
After the researchers adjusted for such potential confounding factors as age, parity, and causes of infertility, IVF-treated women saw a significantly elevated risk for borderline ovarian tumors, compared with subfertile controls (hazard ratio 4.23) and for all ovarian malignancies combined, compared with controls (HR 2.14).
Risk of invasive ovarian cancer was not seen as significantly increased in the IVF-treated women, compared with controls (HR 1.51). However, compared with the general population, the IVF-treated women’s risk of developing invasive ovarian cancer was higher 15 years after IVF treatment, with a standard incidence ratio of 3.54. No increased risk was reported for non-IVF controls, compared with the general population.
Dr. van Leeuwen and her colleagues noted that they did not find evidence that repeated cycles of IVF increased the risk of malignancies, as might be expected. However, they wrote, the powers of their analyses were reduced by missing data and small numbers of women in the subgroups. In the IVF group, 40% of women had one to two stimulated IVF cycles, 39% had three to four cycles, and 21% received five or more cycles.
The type of infertility treatments were as follows: clomiphene/hMG (human menopausal gonadotropins) or FSH (follicle stimulating hormone)/hMG stimulation protocols were used until 1988-1989, whereas stimulation with GnRH (gonadotropin-releasing hormone) agonists became common after 1990 (from 20% in 1986 to about 90% after 1990), the investigators said.
Dr. van Leeuwen and her colleagues cited the large cohort size and long follow-up period as strengths of their study, as well as linkages to population-based cancer and pathology registries, which enabled the investigators to also evaluate the occurrence of borderline ovarian tumors.
They noted as a weakness of their study the fact that their group of subfertile controls was relatively small and that 40% of controls had been prescribed clomiphene, meaning that they were not truly unexposed if the cause of the malignancies was drug related and not related to ovarian puncture. The study was based on IVF treatment protocols through 1995 only, they added.
Still, the researchers concluded that they had demonstrated sufficient risk for women and their physicians to consider when deciding whether to start or continue IVF treatment.
The study was funded by the Dutch Ministry of Health, the Health Research and Development Counsel, and the Netherlands Cancer Institute. J.L.H. Evers declared that he works in a department that has received unrestricted research grants from Merck and Ferring. Neither Dr. van Leeuwen nor any other of her colleagues declared any relevant financial disclosures.
Maybe acupuncture and herbal medicine should be tried first! (mike berkley's note)
Women who have undergone in vitro fertilization appear to have a twofold risk of ovarian malignancies later in life, compared with women with fertility problems who never used IVF.
However, the risk of invasive ovarian cancer was not significantly increased in IVF-treated women until 15 years after IVF treatment, the results of the study found.
Results from a large Dutch cohort study of 25,152 women using linked medical records to identify women who had been seen for infertility and/or treated with IVF from 1983 to 1995 showed that borderline ovarian tumors accounted for most of the increase in risk after a median 15 years of follow-up. Most of the women were in their late 40s at the study end point.
The investigators of the study, which was published Oct. 26 in Human Reproduction, compared the 19,146 IVF-treated women in the cohort with a control group of 6,006 women who had been seen for fertility problems but had not undergone IVF (although they may have received other forms of treatment, including drugs). The investigators also looked at rates of ovarian malignancies in the general population (Hum. Reprod. 2011 [doi:10.1093/humrep/der322]).
Having subfertile controls was important, the investigators said, because women with infertility have a different risk profile for ovarian malignancies than do women in the population at large. Causes of infertility in the study included fallopian tube disorders, subfertility of a male partner, cervical factor, and endometriosis.
The investigators, led by Flora E. van Leeuwen, Ph.D., of the Netherlands Cancer Institute in Amsterdam, noted that the findings of a risk increase for ovarian malignancies confirmed older findings from smaller cohort studies. Borderline tumors are considered to have a low malignancy potential, and not much is known about which will become invasive, but these tumors do require treatment.
Nearly half of the 61 malignancies detected in the IVF-treated women were borderline tumors, while in the general population of women under age 50 years, these normally account for 15%-30% of malignancies, Dr. van Leeuwen and her colleagues found. A high proportion – 63% – of the borderline tumors seen in the IVF-treated group were serous, while mucinous tumors are more frequent in the general population.
After the researchers adjusted for such potential confounding factors as age, parity, and causes of infertility, IVF-treated women saw a significantly elevated risk for borderline ovarian tumors, compared with subfertile controls (hazard ratio 4.23) and for all ovarian malignancies combined, compared with controls (HR 2.14).
Risk of invasive ovarian cancer was not seen as significantly increased in the IVF-treated women, compared with controls (HR 1.51). However, compared with the general population, the IVF-treated women’s risk of developing invasive ovarian cancer was higher 15 years after IVF treatment, with a standard incidence ratio of 3.54. No increased risk was reported for non-IVF controls, compared with the general population.
Dr. van Leeuwen and her colleagues noted that they did not find evidence that repeated cycles of IVF increased the risk of malignancies, as might be expected. However, they wrote, the powers of their analyses were reduced by missing data and small numbers of women in the subgroups. In the IVF group, 40% of women had one to two stimulated IVF cycles, 39% had three to four cycles, and 21% received five or more cycles.
The type of infertility treatments were as follows: clomiphene/hMG (human menopausal gonadotropins) or FSH (follicle stimulating hormone)/hMG stimulation protocols were used until 1988-1989, whereas stimulation with GnRH (gonadotropin-releasing hormone) agonists became common after 1990 (from 20% in 1986 to about 90% after 1990), the investigators said.
Dr. van Leeuwen and her colleagues cited the large cohort size and long follow-up period as strengths of their study, as well as linkages to population-based cancer and pathology registries, which enabled the investigators to also evaluate the occurrence of borderline ovarian tumors.
They noted as a weakness of their study the fact that their group of subfertile controls was relatively small and that 40% of controls had been prescribed clomiphene, meaning that they were not truly unexposed if the cause of the malignancies was drug related and not related to ovarian puncture. The study was based on IVF treatment protocols through 1995 only, they added.
Still, the researchers concluded that they had demonstrated sufficient risk for women and their physicians to consider when deciding whether to start or continue IVF treatment.
The study was funded by the Dutch Ministry of Health, the Health Research and Development Counsel, and the Netherlands Cancer Institute. J.L.H. Evers declared that he works in a department that has received unrestricted research grants from Merck and Ferring. Neither Dr. van Leeuwen nor any other of her colleagues declared any relevant financial disclosures.
Maybe acupuncture and herbal medicine should be tried first! (mike berkley's note)
Tuesday, October 25
Acupuncture: A Cure for Infertility?
Catherine Donaldson-Evans
At 36, Lucy Appert has suffered through two miscarriages, a stillbirth at 8 1/2 months and, because of a rare pregnancy-related liver dysfunction, intensive illness and surgery.
Yet after enduring five painful years of trying to have their own baby, Appert and her husband Edward finally saw their dream come true last month when their son Henry was born — premature, but healthy.
For all the fertility treatments, technologies and prenatal care available to women today, Appert credits the success of her pregnancy to an ancient Chinese secret.
"I recommend acupuncture (search) to everyone," Appert said. "It does work. I did everything possible for years to have a baby. I almost lost hope."
The millennias-old Asian medical practice — in which the acupuncturist places tiny needles in various pressure points, or "Qi" (Chee), in the body to improve circulation and reduce stress — has been around in the United States for years as an "alternative" treatment for numerous ailments.
But recently, acupuncture has been picking up steam as a possible remedy for female infertility, with a handful of American and European studies showing that it enhances the success rate of in vitro fertilization (IVF) (search).
“Do I believe in it? Absolutely,” said Dr. Paul C. Magarelli, an infertility doctor at the Reproductive Medicine & Fertility Center in Colorado Springs, Colo., and co-author of an ongoing study into the use of acupuncture with IVF with Dr. Diane K. Cridennda. Cridennda is a licensed acupuncturist with a master's degree in Oriental medicine from the International Institute of Chinese Medicine (search) who owns East Winds Acupuncture, also in Colorado Springs.
Magarelli said he joined the study at the urging of Cridennda, who had approached him about using acupuncture with IVF based on her knowledge of its history as an Eastern fertility treatment. A skeptic at first, Magarelli said he dismissed the idea for a while before signing on.
"I thought, this is rubbish — it can't be true," Magarelli said. "But no matter how I look at this data, I see an improvement. ... I'm pretty much a convert."
In general, studies seem to indicate that doing acupuncture about 30 minutes before and after in vitro fertilization can increase the chance that the embryo will be implanted successfully and reduce the chance of miscarriage.
There are also indications that the effectiveness of the IVF drugs and procedure may improve if acupuncture is done about once a week in the month or two leading up to the start of IVF and then continued regularly — once or twice a week — during the whole cycle.
And, as in Appert's case, there is anecdotal evidence that acupuncture can help with other fertility and pregnancy problems. Appert didn't need IVF to conceive, but she was told she probably couldn't carry a healthy baby to term because of her liver disorder.
But some doctors caution that there is no "magic pill" for fertility, pregnancy and IVF troubles — whether it's acupuncture or something else.
"The jury is still out on that," said Dr. Eric Surrey, president of the Society for Assisted Reproductive Technology (SART) (search), who has a practice at the Colorado Center for Reproductive Medicine. "I don't think we have good data to show that acupuncture before and after the embryo transfer is truly beneficial."
And they warn against making too much of claims that acupuncture can help with having babies.
"It's impossible to say at this point," said Dr. Robert Schenken, president of the American Society for Reproductive Medicine (ASRM) (search), who has a practice at the University of Texas Health Science Center. "In the absence of any controlled data, I don't think we can come to a firm conclusion."
Promising Research
Acupuncture seems to help some women because it improves circulation to the ovaries (search) — which makes for healthier eggs — and to the uterus (search), which increases the chances that the lining will be strong enough to hold those eggs to full-term.
"Acupuncture provides better circulation and better blood flow to the womb," said Dr. Raymond Chang, director of New York's Meridian Medical Group, who has been incorporating acupuncture into fertility treatments for the past decade. "It will give a better chance for the eggs to be nourished and therefore carried."
There's also the fact that acupuncture can be a stress-reliever during an emotional time.
"Trying to get pregnant is incredibly stressful," said Victoria Koos, the acupuncturist who treated Appert at Yin and Tonic Acupuncture in New York. "They're crossing their fingers. The longer they're trying to get pregnant, the worse it gets ... Part of [acupuncture's success] is simply relaxation. When the body is relaxed, all systems function better."
The Colorado study Magarelli and Cridennda presented at a conference this fall is one of a series the pair have done with acupuncture and in vitro.
That one looked at 114 patients who had a good chance of IVF being effective, some who did acupuncture and some who didn’t. It found, among other things, that there were fewer miscarriages, more pregnancies and a 7 percent higher birth rate among those who got acupuncture treatment over those who didn’t, according to Magarelli.
It piggybacked off other research the team did on 147 “poor responders” to IVF, which found that the pregnancy rate was 40 percent, with 11 percent more babies born, among those who did acupuncture with in vitro fertilization compared to those who didn’t.
In March, Magarelli and Cridennda released findings in Italy involving patients with an average prognosis for IVF success. Those yielded clear numbers that the pregnancy rate increased with acupuncture by 24 percent, according to Magarelli.
“What got us was that now we were seeing a firm trend toward getting more people pregnant,” he said.
The Colorado research seems to support some findings of two earlier studies, one in Germany by lead researcher Dr. Wolfgang E. Paulus — published in ASRM's “Fertility and Sterility” (search) in April 2002 — and one in Sweden by lead researcher Elisabet Stener-Victorin in the 1990s.
Of course, even those who believe in acupuncture concede that while the existing studies have yielded good information, there still isn't sufficient evidence, or a broad enough sample of patients tested, to call acupuncture a proven remedy.
"We are convinced, but scientifically you need proof — or so-called proof," Chang said. "There is a whole set of proof from lab experiments and animal studies to human studies, but it's very difficult to do human studies."
Schenken noted that even though there might be one set of data showing positive results, "it really needs to be corroborated, preferably with several different studies and different patient populations." For example, there can be bias when the entire study sample comes from the same clinic, or when patients know they're doing something different from usual.
Schenken said he doesn't get asked about acupuncture often, but when patients do, "we don't recommend it, but we do not discourage it."
Surrey takes a similar approach. In his opinion, the data "is not bad" on the theory that acupuncture can help when administered before IVF, but as far as acupuncture generally improving fertility or helping after the embryo transfer in IVF, "there really isn't a whole lot of data on that."
But at the very least, "there is absolutely nothing to show that it's harmful if it's done with a trained and appropriately skilled acupuncturist," he said. It's a notion that nearly everyone in the medical field — whether they believe in needles and Qi or not — seems to agree upon.
Some Eastern medicine-Western medicine rivalry may come into play with how to treat reproductive problems, but Chang said he sees more resistance with the use of Chinese herbs — which are ingested — than he does with acupuncture. Often, it's the in vitro specialists themselves who refer their patients to him for acupuncture after a couple of failed IVF attempts.
As for the couples trying to bring a child into the world — particularly through a complicated, invasive procedure like IVF— anything that helps the process along is welcome.
“IVF is so technical that patients feel like they’re being pushed and pulled … with acupuncture, they’re in a sense taking some control,” Magarelli said. "Acupuncture isn't a needle, it's an environment."
Added Koos: "They're on these incredibly strong drugs that make the poor women crazy. They're running around like Catwoman. This is to help them stay sane while they're going through the process."
The emotional cost of infertility comes with a hefty financial price tag as well — in vitro fertilization can cost anywhere from $10,000 to $20,000 a cycle and generally isn't covered by insurance; acupuncture ranges from about $30 to over $200 per treatment — Koos and Chang charge about $90 a pop — and certain health plans do cover at least a portion of it.
Meanwhile, researchers and experts in the field are excited at what they're seeing in the studies. Chang said he's currently working with NYU Medical Center on a trial that looks at IVF with and without acupuncture.
Appert, for her part, was at the end of her rope and felt she had nothing to lose. She started acupuncture with Koos about two months before she began trying to conceive — with needles in her toes and a couple of liver points — and continued with the treatments throughout the pregnancy.
"The first time I went, I was completely terrified. My husband went with me and held my hand," she said. "I could feel the muscles in my liver jump and an electric current going through my body. It was very strange but also felt right."
She said being monitored by both her obstetrician and Koos helped reassure her about what was going on during her high-risk pregnancy.
"She would tell me things about how I was doing physically and then I would go to the doctor and he would tell me the same thing," remembers Appert, who works as a professor.
When she got sick late in the pregnancy, both Koos and Appert's OB/GYN were able to detect when her liver went dangerously haywire and get her to the hospital for delivery six weeks early, before the problem harmed the fetus and caused another stillbirth.
Regardless of the skeptics, Appert said she's relieved that she was finally able to have a nearly full-term baby of her own. At 4 pounds, 6 ounces, Henry has been in intensive care but otherwise is doing "fine."
"It really was a miracle," the new mom gushed. "It's one of these weird things that Western medicine can't explain."
At 36, Lucy Appert has suffered through two miscarriages, a stillbirth at 8 1/2 months and, because of a rare pregnancy-related liver dysfunction, intensive illness and surgery.
Yet after enduring five painful years of trying to have their own baby, Appert and her husband Edward finally saw their dream come true last month when their son Henry was born — premature, but healthy.
For all the fertility treatments, technologies and prenatal care available to women today, Appert credits the success of her pregnancy to an ancient Chinese secret.
"I recommend acupuncture (search) to everyone," Appert said. "It does work. I did everything possible for years to have a baby. I almost lost hope."
The millennias-old Asian medical practice — in which the acupuncturist places tiny needles in various pressure points, or "Qi" (Chee), in the body to improve circulation and reduce stress — has been around in the United States for years as an "alternative" treatment for numerous ailments.
But recently, acupuncture has been picking up steam as a possible remedy for female infertility, with a handful of American and European studies showing that it enhances the success rate of in vitro fertilization (IVF) (search).
“Do I believe in it? Absolutely,” said Dr. Paul C. Magarelli, an infertility doctor at the Reproductive Medicine & Fertility Center in Colorado Springs, Colo., and co-author of an ongoing study into the use of acupuncture with IVF with Dr. Diane K. Cridennda. Cridennda is a licensed acupuncturist with a master's degree in Oriental medicine from the International Institute of Chinese Medicine (search) who owns East Winds Acupuncture, also in Colorado Springs.
Magarelli said he joined the study at the urging of Cridennda, who had approached him about using acupuncture with IVF based on her knowledge of its history as an Eastern fertility treatment. A skeptic at first, Magarelli said he dismissed the idea for a while before signing on.
"I thought, this is rubbish — it can't be true," Magarelli said. "But no matter how I look at this data, I see an improvement. ... I'm pretty much a convert."
In general, studies seem to indicate that doing acupuncture about 30 minutes before and after in vitro fertilization can increase the chance that the embryo will be implanted successfully and reduce the chance of miscarriage.
There are also indications that the effectiveness of the IVF drugs and procedure may improve if acupuncture is done about once a week in the month or two leading up to the start of IVF and then continued regularly — once or twice a week — during the whole cycle.
And, as in Appert's case, there is anecdotal evidence that acupuncture can help with other fertility and pregnancy problems. Appert didn't need IVF to conceive, but she was told she probably couldn't carry a healthy baby to term because of her liver disorder.
But some doctors caution that there is no "magic pill" for fertility, pregnancy and IVF troubles — whether it's acupuncture or something else.
"The jury is still out on that," said Dr. Eric Surrey, president of the Society for Assisted Reproductive Technology (SART) (search), who has a practice at the Colorado Center for Reproductive Medicine. "I don't think we have good data to show that acupuncture before and after the embryo transfer is truly beneficial."
And they warn against making too much of claims that acupuncture can help with having babies.
"It's impossible to say at this point," said Dr. Robert Schenken, president of the American Society for Reproductive Medicine (ASRM) (search), who has a practice at the University of Texas Health Science Center. "In the absence of any controlled data, I don't think we can come to a firm conclusion."
Promising Research
Acupuncture seems to help some women because it improves circulation to the ovaries (search) — which makes for healthier eggs — and to the uterus (search), which increases the chances that the lining will be strong enough to hold those eggs to full-term.
"Acupuncture provides better circulation and better blood flow to the womb," said Dr. Raymond Chang, director of New York's Meridian Medical Group, who has been incorporating acupuncture into fertility treatments for the past decade. "It will give a better chance for the eggs to be nourished and therefore carried."
There's also the fact that acupuncture can be a stress-reliever during an emotional time.
"Trying to get pregnant is incredibly stressful," said Victoria Koos, the acupuncturist who treated Appert at Yin and Tonic Acupuncture in New York. "They're crossing their fingers. The longer they're trying to get pregnant, the worse it gets ... Part of [acupuncture's success] is simply relaxation. When the body is relaxed, all systems function better."
The Colorado study Magarelli and Cridennda presented at a conference this fall is one of a series the pair have done with acupuncture and in vitro.
That one looked at 114 patients who had a good chance of IVF being effective, some who did acupuncture and some who didn’t. It found, among other things, that there were fewer miscarriages, more pregnancies and a 7 percent higher birth rate among those who got acupuncture treatment over those who didn’t, according to Magarelli.
It piggybacked off other research the team did on 147 “poor responders” to IVF, which found that the pregnancy rate was 40 percent, with 11 percent more babies born, among those who did acupuncture with in vitro fertilization compared to those who didn’t.
In March, Magarelli and Cridennda released findings in Italy involving patients with an average prognosis for IVF success. Those yielded clear numbers that the pregnancy rate increased with acupuncture by 24 percent, according to Magarelli.
“What got us was that now we were seeing a firm trend toward getting more people pregnant,” he said.
The Colorado research seems to support some findings of two earlier studies, one in Germany by lead researcher Dr. Wolfgang E. Paulus — published in ASRM's “Fertility and Sterility” (search) in April 2002 — and one in Sweden by lead researcher Elisabet Stener-Victorin in the 1990s.
Of course, even those who believe in acupuncture concede that while the existing studies have yielded good information, there still isn't sufficient evidence, or a broad enough sample of patients tested, to call acupuncture a proven remedy.
"We are convinced, but scientifically you need proof — or so-called proof," Chang said. "There is a whole set of proof from lab experiments and animal studies to human studies, but it's very difficult to do human studies."
Schenken noted that even though there might be one set of data showing positive results, "it really needs to be corroborated, preferably with several different studies and different patient populations." For example, there can be bias when the entire study sample comes from the same clinic, or when patients know they're doing something different from usual.
Schenken said he doesn't get asked about acupuncture often, but when patients do, "we don't recommend it, but we do not discourage it."
Surrey takes a similar approach. In his opinion, the data "is not bad" on the theory that acupuncture can help when administered before IVF, but as far as acupuncture generally improving fertility or helping after the embryo transfer in IVF, "there really isn't a whole lot of data on that."
But at the very least, "there is absolutely nothing to show that it's harmful if it's done with a trained and appropriately skilled acupuncturist," he said. It's a notion that nearly everyone in the medical field — whether they believe in needles and Qi or not — seems to agree upon.
Some Eastern medicine-Western medicine rivalry may come into play with how to treat reproductive problems, but Chang said he sees more resistance with the use of Chinese herbs — which are ingested — than he does with acupuncture. Often, it's the in vitro specialists themselves who refer their patients to him for acupuncture after a couple of failed IVF attempts.
As for the couples trying to bring a child into the world — particularly through a complicated, invasive procedure like IVF— anything that helps the process along is welcome.
“IVF is so technical that patients feel like they’re being pushed and pulled … with acupuncture, they’re in a sense taking some control,” Magarelli said. "Acupuncture isn't a needle, it's an environment."
Added Koos: "They're on these incredibly strong drugs that make the poor women crazy. They're running around like Catwoman. This is to help them stay sane while they're going through the process."
The emotional cost of infertility comes with a hefty financial price tag as well — in vitro fertilization can cost anywhere from $10,000 to $20,000 a cycle and generally isn't covered by insurance; acupuncture ranges from about $30 to over $200 per treatment — Koos and Chang charge about $90 a pop — and certain health plans do cover at least a portion of it.
Meanwhile, researchers and experts in the field are excited at what they're seeing in the studies. Chang said he's currently working with NYU Medical Center on a trial that looks at IVF with and without acupuncture.
Appert, for her part, was at the end of her rope and felt she had nothing to lose. She started acupuncture with Koos about two months before she began trying to conceive — with needles in her toes and a couple of liver points — and continued with the treatments throughout the pregnancy.
"The first time I went, I was completely terrified. My husband went with me and held my hand," she said. "I could feel the muscles in my liver jump and an electric current going through my body. It was very strange but also felt right."
She said being monitored by both her obstetrician and Koos helped reassure her about what was going on during her high-risk pregnancy.
"She would tell me things about how I was doing physically and then I would go to the doctor and he would tell me the same thing," remembers Appert, who works as a professor.
When she got sick late in the pregnancy, both Koos and Appert's OB/GYN were able to detect when her liver went dangerously haywire and get her to the hospital for delivery six weeks early, before the problem harmed the fetus and caused another stillbirth.
Regardless of the skeptics, Appert said she's relieved that she was finally able to have a nearly full-term baby of her own. At 4 pounds, 6 ounces, Henry has been in intensive care but otherwise is doing "fine."
"It really was a miracle," the new mom gushed. "It's one of these weird things that Western medicine can't explain."
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